In which disorder, change of single base pair in the gene for \beta globin chain results in change of glutamic acid to valine?
Thalassemia
Sickle cell anemia
Haemophilia
Phenylketonuria
, Sickle-cell anaemia is caused by the substitution of Glutamic acid (Glu) by Valine (Val) at the sixth position of the \beta globin chain of the haemoglobin molecule. This substitution results from a single base substitution at the sixth codon of the \beta globin gene from GAG to GUG .
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