Under which of the following conditions will there be no change in the reading frame of the following mRNA? 5'AACAGCGGUGCUAUU 3'
Deletion of GGU from 7th, 8th and 9th positions
Insertion of G at the 5th position
Deletion of G from the 5th position
Insertion of A and G at the 4th and the 5th positions respectively
According to the text regarding mutations and the genetic code, insertion or deletion of one or two bases changes the reading frame from the point of insertion or deletion (frame-shift mutation). However, insertion or deletion of three or its multiple bases results in the insertion or deletion of one or multiple amino acids, and the reading frame remains unaltered from that point onwards. Therefore, deleting three bases (GGU) will not shift the reading frame.
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