Sickle cell anaemia is due to:
Change of Amino Acid in \alpha -chain of Haemoglobin.
Change of Amino Acid in \beta -chain of Haemoglobin.
Change of Amino acid in both \alpha and \beta chains of Haemoglobin.
Change of Amino acid either \alpha or \beta chain of Haemoglobin.
, the defect in sickle-cell anaemia is caused by the substitution of Glutamic acid (Glu) by Valine (Val) at the sixth position of the \beta globin chain of the haemoglobin molecule . This change results from a single base substitution (point mutation) at the sixth codon of the \beta globin gene from GAG to GUG .
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