Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R). Assertion (A): FSH which interacts with membrane bound receptors does not enter the target cell. Reason (R): Binding of FSH to its receptors generates second messenger (cyclic AMP) for its biochemical and physiological responses. In the light of the above statements, choose the most appropriate answer from the options given below:
Both (A) and (R) are True and (R) is the correct explanation of (A).
Both (A) and (R) are True but (R) is not the correct explanation of (A).
(A) is True but (R) is False.
(A) is False but (R) is True.
FSH is a pituitary hormone, which falls under the category of peptide/protein hormones . Hormones that interact with membrane-bound receptors (like FSH) normally do not enter the target cell; therefore, Assertion (A) is True . Binding of such hormones to their receptors generates second messengers (e.g., cyclic AMP, IP3, Ca++) which regulate cellular metabolism; therefore, Reason (R) is True . However, the generation of the second messenger is the mechanism of action that follows binding, not the cause of the hormone's inability to enter the cell. The inability to enter is due to the lipid-insoluble nature of protein hormones. Thus, (R) is not the correct explanation of (A).
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