The reaction of a Grignard reagent (R−Mg−X) with carbon dioxide (CO2) is a standard method for the preparation of carboxylic acids.
- Nucleophilic Attack: The alkyl group (R−) of the Grignard reagent acts as a nucleophile and attacks the electrophilic carbon of CO2 (O=C=O).
- Intermediate: This forms an addition product, a salt of the carboxylic acid (R−COO−Mg+X).
- Hydrolysis: Upon acidification (hydrolysis with H3O+), the salt is converted into the corresponding carboxylic acid (RCOOH).
R−Mg−X+O=C=O→R−C(OMgX)=OH3O+R−COOH