Consider the reaction: This reaction will be the fastest in
ethanol
methanol
N,N'-dimethylformamide (DMF)
water
The given reaction is an nucleophilic substitution reaction, as it involves a primary alkyl halide (1-bromopropane) reacting with a strong nucleophile (). reactions proceed fastest in polar aprotic solvents. These solvents effectively solvate cations (like ) but do not strongly solvate anions (like ) via hydrogen bonding, leaving the nucleophile highly reactive. Among the given options, water, methanol, and ethanol are polar protic solvents. N,N'-dimethylformamide (DMF) is a polar aprotic solvent, making it the ideal choice to accelerate this reaction.
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