Alcohols ($R-OH$) act as nucleophiles due to the presence of lone pairs on the oxygen atom. They undergo nucleophilic acyl substitution reactions with acid derivatives like Acid Chlorides ($CH_3COCl$) and Acid Anhydrides ($(CH_3CO)_2O$) to form esters.

1. With $CH_3COCl$: $R-OH + CH_3COCl \rightarrow CH_3COOR + HCl$ (Vigorous reaction).
2. With Acetic Anhydride: $R-OH + (CH_3CO)_2O \rightarrow CH_3COOR + CH_3COOH$ (Reaction occurs in presence of acid/base).
3. With Ether: Ethers ($R-O-R'$) are quite stable towards nucleophilic attack because the alkoxide ion ($RO^-$) is a poor leaving group. Therefore, alcohols do not react with ethers via nucleophilic substitution under standard conditions.

Thus, Ether is the compound that does not give nucleophilic substitution with alcohol.