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NEET CHEMISTRYMedium

The esters that get hydrolyzed most easily under alkaline conditions is?

A

Option 1 (Image Missing)

B

Option 2 (Image Missing)

C

Option 3 (Image Missing)

D

Option 4 (Image Missing)

Step-by-Step Solution

Alkaline hydrolysis of esters (saponification) is a nucleophilic acyl substitution reaction where a nucleophile (OHOH^-) attacks the electrophilic carbonyl carbon.

  1. Electronic Effect: The presence of Electron-Withdrawing Groups (EWG) (such as NO2-NO_2, Cl-Cl, or halogen atoms) on the ester molecule withdraws electron density from the carbonyl carbon. This increases the positive charge on the carbon, making it more susceptible to nucleophilic attack by OHOH^-, thus increasing the rate of hydrolysis.
  2. Steric Effect: Bulky groups near the carbonyl carbon hinder the approach of the nucleophile, decreasing the rate.

Therefore, the ester with the strongest electron-withdrawing substituent (and least steric hindrance) will hydrolyze most easily.

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