RNA and DNA are chiral molecules, their chirality is due to:
L-sugar component
chiral bases
chiral phosphate ester units
D-sugar component
The chirality of DNA and RNA is due to the presence of their pentose sugar components, which are D-ribose in RNA and D-2-deoxyribose in DNA. These sugar molecules contain multiple chiral carbon centers. In contrast, the nitrogenous bases (purines and pyrimidines) are planar and achiral, and the phosphate ester units are also achiral.
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