According to the collision theory of chemical reactions, not all collisions lead to the formation of products. The collisions in which molecules collide with sufficient kinetic energy (called threshold energy) and proper orientation, so as to facilitate the breaking of old bonds between reacting species and the formation of new bonds to form products, are called effective collisions. Therefore, statements A, B, C, and E are correct. A high activation energy means a higher energy barrier, which would actually result in fewer effective collisions, so statement D is incorrect.