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NEET Hard

Calcium is important in skeletal muscle contraction because it

1

Detaches the myosin head from the actin filament.

2

Activates the myosin ATPase by binding to it.

3

Binds to troponin to remove the masking of active sites on actin for myosin.

4

Prevents the formation of bonds between the myosin cross bridges and the actin filament.

Step-by-Step Solution

Signal for contraction increase Ca++Ca^{++} level many folds in the sarcoplasm. Ca++Ca^{++} now binds with sub-unit of troponin (troponin "C") which is masking the active site on actin filament and displaces the sub-unit of troponin. Once the active site is exposed, head of the myosin attaches and initiate contraction by sliding the actin over myosin.

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