In higher vertebrates, the immune system can distinguish between self-cells and non-self. If this property is lost due to genetic abnormality and it attacks self–cells, then it leads to:
graft rejection
auto-immune disease
active immunity
allergic response
Higher vertebrates have evolved a memory-based acquired immunity that can distinguish foreign organisms from self-cells. However, sometimes due to genetic and other unknown reasons, the body attacks self-cells. This results in damage to the body and is called auto-immune disease Rheumatoid arthritis is an example of such a disease Graft rejection is caused by the cell-mediated immune response distinguishing 'non-self' tissue
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