Question
The genetic defect-Adenosine Deaminase (ADA) deficiency may be cured permanently by:
periodic infusion of genetically engineered lymphocytes having functional ADA cDNA
administering adenosine deaminase activators
introducing bone marrow cells producing ADA into cells at early embryonic stages
invitro cell culture therapy
treatments like bone marrow transplantation and enzyme replacement therapy are not completely curative. Gene therapy involving the infusion of genetically engineered lymphocytes requires periodic infusion because these cells are not immortal. However, if the gene isolated from marrow cells producing ADA is introduced into cells at early embryonic stages, it could be a permanent cure .
This question aligns with the NEET BIOLOGY syllabus, specifically targeting concepts from Biotechnology and its Applications. Mastering this topic is crucial for scoring well in the upcoming medical entrance examinations. Solving conceptually related problems will help you understand the nuances of these concepts and improve your problem-solving speed.
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