Question
With regard to insulin, choose the correct options:
(a), (c) and (d) only
(a) and (d) Only
(b) and (d) only
(b) and (c) only
insulin consists of two short polypeptide chains: chain A and chain B, that are linked together by disulphide bridges . In mammals, insulin is synthesised as a pro-hormone which contains an extra stretch called the C peptide . This C peptide is not present in the mature insulin and is removed during maturation into insulin . Genetically engineered insulin (e.g., by Eli Lilly) involves producing chains A and B separately and combining them, meaning the C peptide is absent in the therapeutic product . Therefore, statements referring to the absence of C-peptide in mature insulin, the presence of C-peptide in pro-insulin, and the disulphide linkage are correct.
This question aligns with the NEET BIOLOGY syllabus, specifically targeting concepts from Biotechnology and its Applications. Mastering this topic is crucial for scoring well in the upcoming medical entrance examinations. Solving conceptually related problems will help you understand the nuances of these concepts and improve your problem-solving speed.
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