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neet BIOLOGYMedium

Given below are two statements: one is labeled as Assertion (A) and the other is labeled as Reason (R). Assertion (A): The nematode cannot survive in a transgenic host which expresses specific interfering RNA. Reason (R): Nematode-specific gene introduced in the host produces both sense and antisense complementary RNA which initiate RNA interference in the host cell. In light of the above statement, choose the most appropriate answer from the option given below :

A

(A) is True but (R) is False.

B

(A) is False but (R) is True.

C

Both (A) and (R) are True and (R) is the correct explanation of (A).

D

Both (A) and (R) are True but (R) is not the correct explanation of (A).

Step-by-Step Solution

nematode-specific genes were introduced into the host plant (e.g., tobacco) using Agrobacterium vectors. This introduction was designed to produce both sense and anti-sense RNA in the host cells. These two RNAs, being complementary, formed a double-stranded RNA (dsRNA) that initiated RNA interference (RNAi), silencing the specific mRNA of the nematode. As a consequence of this specific interfering RNA expression (caused by the mechanism described in the Reason), the parasite could not survive in the transgenic host , , .

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