Question
Reason for trisomy in Down's syndrome is:
Non-disjunction during sperm formation
Non-disjunction during egg formation
Non-disjunction at the time of egg or sperm formation
Addition of one extra chromosome during mitosis
, Down's syndrome is caused by the presence of an additional copy of chromosome number 21 (trisomy of 21). This aneuploidy results from the failure of segregation of chromatids during the cell division cycle (meiosis) results in the gain or loss of a chromosome. This failure of segregation, known as non-disjunction, can occur during the formation of either the egg or the sperm, leading to a gamete with an extra chromosome , .
This question aligns with the NEET BIOLOGY syllabus, specifically targeting concepts from Principles of Inheritance and Variation. Mastering this topic is crucial for scoring well in the upcoming medical entrance examinations. Solving conceptually related problems will help you understand the nuances of these concepts and improve your problem-solving speed.
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