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NEET BIOLOGYPrinciples of Inheritance and VariationMedium

Question

Select the correct statements about sickle cell anemia: A: There is a change in the gene for beta-globin B: In beta-globin, there is a valine in place of Lysine C: It is an example of point mutation D: In the normal gene, U is replaced by A

Choose the correct answer from the options given below:

A

(B), (C) and (D) only

B

(B) and (D) only

C

(A), (B) and (D) only

D

(A) and (C) only

Step-by-Step Solution

:

  • Statement A is Correct: Sickle-cell anaemia is caused by a defect in the gene coding for the \beta globin chain of haemoglobin .
  • Statement B is Incorrect: The defect causes the substitution of Glutamic acid (Glu) by Valine (Val) at the sixth position, not Lysine .
  • Statement C is Correct: It is a classic example of a point mutation (change of a single base pair) .
  • Statement D is Incorrect: The mutation results from a single base substitution at the sixth codon of the \beta globin gene from GAG to GUG . Genes (DNA) do not contain Uracil (U); they contain Thymine. Furthermore, the substitution is A to U in mRNA (or A to T in DNA), not U replaced by A.

Exam Context & Concepts Covered

This question aligns with the NEET BIOLOGY syllabus, specifically targeting concepts from Principles of Inheritance and Variation. Mastering this topic is crucial for scoring well in the upcoming medical entrance examinations. Solving conceptually related problems will help you understand the nuances of these concepts and improve your problem-solving speed.

BIOLOGYPrinciples of Inheritance and Variationselectcorrectstatementssickleanemia

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